Siddhartha Roy Group
Laboratory of Protein Biochemistry, Biophysics and Structural Biology
at CSIR - Indian Institute of Chemical Biology
Siddhartha Roy, PhD
Academics & Honours
Ph.D (2007) Indian Institute of Science,
Bangalore, India
Post-doctoral Research Fellow (2008-2010) University of Colorado Denver, Aurora, USA
Post-doctoral Research Fellow (2010-2012)
MD Anderson Cancer Center, Houston, USA
Young Scientist Award (ASCA-04), 2004
Ramanujan Fellow, DST (2013)
Positions Held
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Research Interests
Senior Scientist (2012-2016)
CSIR -Indian Institute of Chemical Biology,
Kolkata, India
Principal Scientist (2016 - 2021)
CSIR -Indian Institute of Chemical Biology,
Kolkata, India
Senior Principal Scientist (2021 - Present)
CSIR -Indian Institute of Chemical Biology, Kolkata, India
Grants & supports
2013-2018
Structural characterization of histone interacting proteins from Plasmodium falciparum
Ramanujan Fellowship
2018-2021
Structural and functional characterization of TSPYL1, a novel histone chaperone implicated in Sudden infant death with dysgenesis of the testes syndrome (SIDDT) in human
Dept. of Science and Technology, Govt of India
2018-2021
Histone chaperon Asf1 in Plasmodium falciparum: Novel anti-malarial targets
Dept. of Biotechnology, Govt of India
2023-Present
Structural characterization of epigenetic modulators implicated in Neural Differentiation
Dept. of Biotechnology, Govt of India
2023-Present
Elucidating the structural and functional role of histone chaperones in rare diseases
Core Research Grant, Dept. of Science and Technology, Govt of India
The focus of our laboratory is to unravel the three dimensional structures of particular proteins which would help elucidate their role in regulating gene expression and other processes involved in chromatin dynamics. We intend to explore the structure/function relationship and dynamicity of these macromolecules using X-ray crystallography and study protein-protein interaction with their binding partners and substrates using biophysical and biochemical approaches to unravel their importance and the fate in their misregulation in cancer, infectious diseases and metabolic disorders.
Current Research Interest:
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Structure-guided designing of inhibitor molecules against epigenetic enzymes involved in metabolic disorders in human.
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Insights into structural and functional aspects of histone chaperones involved in the DNA damage repair pathways and their role in rare diseases.
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Structural and functional characterization histone ubiquitin ligases in different disease contexts.